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(215) 390-1449
 Text: (215) 999-3376

Expert Dermatologists. Excellent Care

Request Appointment Conditions We Treat
  • AAD
  • Dr Perlis ABD seal
  • ACMS

Why Choose Keystone Dermatology?

We are experts in skin cancer detection and removal, and our surgeons specialize in the Mohs technique. Our physicians and nurse practitioner are involved in teaching and medical education at both a community hospital and university medical center level, as well as contributing to national news media.

  • Philadephia Magazine Top Doctors 2022
  • Philadephia Magazine Top Doctors 2021
  • Philadephia Magazine Top Doctors 2020
  • Philadephia Magazine Top Doctors 2019
  • Philadephia Magazine Top Doctors 2018
  • Philadephia Magazine Top Docs 2017
  • Philadephia Magazine Top Docs 2016
  • Philadephia Magazine Top Docs 2015
  • Philadephia Magazine Top Docs 2014
  • Philadephia Magazine Top Docs 2013
*Dr. Perlis
Medical Dermatology

Medical Dermatology

  • Acne
  • Moles
  • Eczema
  • Psoriasis
  • Contact Dermatitis
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Surgical Dermatology

Surgical Dermatology

  • Mohs Micrographic Surgery
  • Skin Cancer Excision
  • Cosmetic Removal
  • Ear Lobe Repair

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Cosmetic Dermatology

Cosmetic Dermatology

  • Botulinum toxin treatments (Botox, Xeomin, Dysport, Juveau)
  • Chemical peels
  • Dermal fillers (Restylane, Juvederm, Belotero, Radiesse, Versa, etc.)
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Years of Combined Experience
MOHS Surgeries Performed
Stars on Google
Year Top Docs
Have Questions? Please Call (215) 390-1449 or text us at (215) 999-3376

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World Class Care

  • World-class Providers
  • State-of-the-Art Facilities
  • Full Range of Services
  • Cutting-Edge Technology

For Busy People

  • Appointments readily available
  • On-time service
  • Monday (7 AM – 5 PM)
  • Tuesday (7 AM – 5 PM)
  • Wednesday (7 AM – 6:30 PM)
  • Thursday (7 AM – 5 PM)
  • Friday (7 AM - 3 PM)
  • Multiple convenient locations
  • Email:

You’re Covered

  • Blue Cross Blue Shield PPO
  • Medicare
  • Most commercial PPO plans
  • Exchange-based PPO plans
  • And more

Real Patient Reviews

Non-surgical procedures

“Intelligent, comforting, sympathetic...”

Dr. Perlis is an exceptional doctor! He is intelligent, comforting, sympathetic, as well as skilled and determined to find you answers. He made himself readily available when I needed help and was able to diagnose me with a rare disease and start me on a path to get help within a couple visits whereas some people spend years trying to get diagnosed! I highly recommend Dr. Perlis (as well as Dr. Roman) and the team at Keystone Dermatology Partners!

“Genuinely concerned for his patients”

The staff are very friendly and professional. The office has a very nice environment. I purposely traveled from the Fox Chase area of Philadelphia to this office in King Of Prussia to see Dr. Clifford Perlis. He performed MOHS surgery on my face years ago and did a wonderful job in removing the basal cell carcinoma and in leaving a minimal scar. Plus he is genuinely concerned for his patients. I highly recommend this practice.

“Everyone there is great!!”

I highly recommend Keystone Dermatolgy Partners. I met with Karen Limaye,NP and Trish, her nurse at the KOP office. I had struggled with severe contact dermatitis on my lips for 5-6 months. Saw 2 others dermatologists but it never fully resolved. The first ointment Karen prescribed gave me relief very next day! Alleluia! Lips have improved so much & feel “normal” again. Thanks Karen & staff. Everyone there is great!!

“Amazing Results!”

Amazing Results! After only 2 weeks I am without pain from my Psoriasis. After 6 years I can finally see my elbows clear. I had given up with others handing me countless creams that did nothing. They tackled the problem and had to experience to actually help me. I am beyond moved…hard to write even a factor of my awe. Thank you for helping me!

“Top notch in patient treatment”

My wife has been a patient of Dr. Cliff Perlis for a few years.

Appointments are timely, that is, no delays in the waiting room. He is top notch in patient treatment and mannerisms. It doesn’t get any better than that.

“I felt safe, secure and in excellent medical hands”

Dr. Perlis is the BEST Dermatologist. He performed a MOHS procedure on my nose. I felt safe, secure and in excellent medical hands. A visit to check on my nose with Dr. DeHoratius was also an excellent medical experience. I totally recommend Keystone Dermatology Partners.

“Dr. Perlis is a very kind and thorough doctor”

It was a very positive experience. Dr. Perlis is a very kind and thorough doctor. I highly recommend him.

“The whole office was very professional”

Great office reception. Helen and Robin made me extremely comfortable. The whole office was very professional, and Dr. Perlis was great. This review is from patient “IG”.

“I like my visit very much”

He is very good in explaining all my issues. I like my visit very much. Staffs are so nice n helpful.

“Very understanding and professional doctor”

I had the opportunity to meet Doctor Misha Mutizwa today and he was a very understanding and professional doctor. He accommodated my every need I would highly recommend him to anybody.

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See Our Most Recent Blog Post

Is Bigger Always Better?

When it comes to sunscreen, does a bigger (higher) SPF number mean its better than one with a smaller one? There has historically been some confusion about the SPF number required to achieve adequate protection from the sun. It has not always been clear if SPF 15 is enough or newer SPF 100+ lotions are […]

Read More
Have Questions? Please Call (215) 390-1449